The first sign of cellular aging is the shortening of the telomeres. Telomeres shorten over time and are associated with both aging and aging-related diseases. Environmental factors such as Diet and lifestyle affect the number of shortened telomeres. Telomerase can make this shortening reversible. The telomerase activated by natural molecules is considered an anti-aging modulator and can play an important role in the treatment of aging and aging-related diseases.

In the reverse aging project, diet and lifestyle are the most important contributing factors when it comes to longevity and healthy aging. Many mechanisms and pathways such as diet and lifestyle form the basis for longevity, including telomere length modulation.